Lactoferrin – a key antiviral ingredient in Biozin brand products to combat COVID-19.

The results of all studies show that lactoferrin can be used in
asymptomatic or mildly symptomatic patients,
to prevent SARS-CoV2 from worsening. The ideal dose of lactoferrin should
be varied based on the severity of symptoms.

The respiratory disease caused by the new SARS-CoV-2 and called COVID-19
spreads rapidly, causing fever, fatigue, dry cough and in severe cases,
pneumonia and severe acute respiratory syndrome (1).
A healthy and strong immune system is essential for maintaining our body
healthy and to fight infections.

The products of the Biozin line have a specific composition created specifically to strengthen
the host's immune system also against the invasion of the new SARS-CoV-2.
An essential component is LACTOFERIN.

Lactoferrin is a multifunctional protein present in external secretions and important
component of leukocytes (2).
Lactoferrin has the following actions:

1. As a natural barrier of both respiratory and intestinal mucosa;
2. By restoring iron disorders associated with viral colonization;
3. Antiviral against a wide range of viruses, including SARS-CoV-2, a strain of
   species of SARS-CoV that causes COVID-19.
4. Immunomodulatory and anti-inflammatory action by modulating the immune response, or
   down-regulates pro-inflammatory cytokines, TNF alpha, IL-6, released by the viral
   inflammation, without the risk of possible side effects.

The initial contact between SARS-CoV-2 and host cells is enabled by
cell surface heparan sulfate proteoglycans (HSPGs). SARS-CoV is rolling
on the cell membrane by binding to HSPGs and seeks out specific entry receptors
(ACE2, highly expressed on human lung alveolar epithelial cells) (3),
resulting in subsequent cell entry. Lactoferrin (LF) detects HSPG on
the cell surface, connects them and prevents preliminary interaction between
the virus and host cells and the subsequent process of internalization (4,5)

.

Cavisept SPRAY NASALE is an aqueous solution/spray for the nose/ with hyaluronic acid, glyceric acid
acid, beta-d-glucan and lactoferrin, which, injected into the nasal cavities, allows
the formation of a protective mucoadhesive film, keeping the nasal mucosa from contact with
airborne microbial species and balancing nasal secretions. Recommended first
flu symptoms and to relieve nasal congestion symptoms and prevent
infections of the nasal cavities and upper respiratory tract. It is useful for promoting
the liquefaction of the nasal secretions and consequent removal thereof, as by this
way aids breathing.